| Children |
| | 1. Magdalena Colón Toledo, b. Santo Domingo, CAdiz, Andalucia, Spain [natural] |
| | 2. Leonor Zuazo Colón Toledo, b. Santo Domingo, CAdiz, Andalucia, Spain [natural] |
| + | 3. Felipa Colón Toledo, b. 1510, Santo Domingo, CAdiz, Andalucia, Spain d. 1545, Santo Domingo, CAdiz, Andalucia, Spain (Age 35 years) [natural] |
| | 4. Francisco Colón Toledo, b. 1510, Santo Domingo, CAdiz, Andalucia, Spain d. 1546 (Age 36 years) [natural] |
| | 5. María Colón Toledo, b. Abt 1511, Santo Domingo, CAdiz, Andalucia, Spain d. Abt 1578, Santo Domingo, CAdiz, Andalucia, Spain (Age 67 years) [natural] |
| | 6. Isabel Colón Toledo, b. 1513, Santo Domingo, CAdiz, Andalucia, Spain d. Abt 1578, Santo Domingo, CAdiz, Andalucia, Spain (Age 65 years) [natural] |
| | 7. Juana Colón Toledo, b. 1516, Madrid, Madrid, Madrid, Spain d. 1592, Santo Domingo, CAdiz, Andalucia, Spain (Age 76 years) [natural] |
| | 8. Duke of Veragua Luis Colon Moniz, b. 19 Feb 1522, Santo Domingo, CAdiz, Andalucia, Spain d. 3 Feb 1572, Oran, Oran, Algeria (Age 49 years) [natural] |
| + | 9. Cristobal Colón Toledo, b. Abt 1523, LOS ALCARRIZOS, SANTO DOMINGO, REPUBLICA DOMINICANA d. Abt 1571, Peru (Age 48 years) [natural] |
| | 10. Diego Colón Toledo, b. Abt 1524, Santo Domingo, CAdiz, Andalucia, Spain d. Abt 1546, Nombre de Dios, Cocle, Panama (Age 22 years) [natural] |
| | 11. Bartolo Colón Toledo, b. 1525, Dominican Republic [natural] |
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