| Children |
| | 1. Isabel Fernandez Rodriguez [natural] |
| | 2. Hernando Colombo [natural] |
| | 3. Ana Gurrea, b. 1470 d. 1572, Zaragoza  (Age 102 years) [natural] |
| | 4. Ferdinand Colon, b. 1471, Lisboa, Lisboa, Portugal d. 12 Jul 1539, Sevilla, Seville, Andalucia, Spain (Age 68 years) [natural] |
| | 5. Diego Moniz Colon, b. 1 Apr 1479, Porto Santo, Madeira, Portugal d. 23 Feb 1526, La Puebla de Montalban, Spain (Age 46 years) [natural] |
| | 6. Diego Perestrella E Colón, b. 1480, Vila Baleira, Porto Santa, Madeira, Portugal d. 23 Feb 1526, Toledo, Castilla-La Mancha, Spain (Age 46 years) [natural] |
| | 7. Joseph Colombus, b. 13 Jul 1483, West London, London, England d. 24 Mar 1544, London, London, England (Age 60 years) [natural] |
| | 8. Fernando Hernando Colon Columbus Colombo,, b. 14 Aug 1488, Córdoba, Provincia de Córdoba, Andalucia, Spain d. 12 Jul 1539, Sevilla, Provincia de Sevilla, Andalucia, Spain (Age 50 years) [natural] |
| | 9. Linda Colombus, b. 23 Feb 1501, London, London, England d. 24 Sep 1551, London, London, England (Age 50 years) [natural] |
|
