Juan married Juana López Espinosa in 1740 in Coamo, Coamo, Puerto Rico, United States. Juana (daughter of Nicolas López Colon Alicea and Isabel Espinosa Díaz, daughter of Manuel López Alicea and Isabel Espinosa Díaz, daughter of Nicolas López Colon Alicea and Catalina Espinosa Díaz) was born on 4 Nov 1715 in Coamo, Coamo, Puerto Rico, Province of Spain; died on 15 Nov 1795 in Cayey, Cayey, Puerto Rico, ESP. [Group Sheet] [Family Chart]

1. Juan Rodríguez Vazquez was born on 18 Jul 1811 in Cayey, Cayey, Puerto Rico, USA; died on 3 Aug 1869 in Cayey, Cayey, Puerto Rico, USA.
2. María Rosa Rodríguez Vazquez was born on 11 Aug 1802 in Cayey, Cayey, Puerto Rico, USA; died about 1851 in Cayey, Cayey, Puerto Rico, USA.
3. Juana Julia Justa Rodríguez López was born in 1750 in Cayey, Cayey, Puerto Rico, USA; died on 13 Aug 1836 in Cayey, Cayey, Puerto Rico, USA.
4. Kristy Santana Craig (Rich)
5. Roberto Antonio Acevedo Santana was born on 5 Oct 1971 in Fajardo, Puerto Rico, USA; died on 29 Jan 2021 in Tampa, Hillsborough, Florida, USA; was buried in Gotha, Orange, Florida, USA.
6. María Rodríguez López was born about 1746 in Coamo, Coamo, Puerto Rico, Province of Spain; died on 1 May 1789 in Coamo, Coamo, Puerto Rico, Province of Spain.
7. Bernarda Rodríguez Vazquez was born on 10 Jun 1790 in Cayey, Cayey, Puerto Rico, USA; died about 1890 in Cayey, Cayey, Puerto Rico, USA.
8. Antonio Rodríguez Vazquez was born on 21 Jan 1786 in Cayey, Cayey, Puerto Rico, USA; died in UNKNOWN in Cayey, Cayey, Puerto Rico, USA.
9. Juan Leonardo Rodríguez López died on 2 Mar 1833 in Cayey, Cayey, Puerto Rico, USA.

Juan married María Delgado in UNKNOWN. María was born about 1680 in Coamo, Coamo, Puerto Rico, United States; died before 1720 in Coamo, Coamo, Puerto Rico, United States. [Group Sheet] [Family Chart]