José married Angela Vázquez Rivera on 2 Jan 1795 in Cayey, Cayey, Puerto Rico, USA. Angela (daughter of Manuel Vázquez Rivera and María Encarnación Rivera Colón) was born in 1767 in Cayey, Cayey, Puerto Rico, Province of Spain; died on 3 Jun 1832 in Cayey, Cayey, Puerto Rico, Province of Spain. [Group Sheet] [Family Chart]

1. María Josefa Santiago Vázquez was born on 29 Apr 1798 in Cayey, Puerto Rico, Province of Spain; died on 13 Oct 1834 in Cayey, Puerto Rico, Province of Spain.
2. María Silvestra Santiago Vazquez was born on 31 Dec 1799 in Cayey, Cayey, Puerto Rico, USA; died about 1879 in Cayey, Cayey, Puerto Rico, USA.