Santos married Carmen Aponte Rivera on 17 Dec 1927 in Guayama, Guayama, Puerto Rico, USA. Carmen (daughter of Desiderio Aponte López and Estefanía Rivera) was born on 5 Feb 1908 in Mayaguez, Puerto Rico, US Territorries; died on 7 Dec 1993 in Guayama, Guayama, Puerto Rico, USA. [Group Sheet] [Family Chart]

1. Sindulfa Colón Aponte was born on 2 Mar 1922 in Puerto Rico, USA; died in 2010 in Puerto Rico, USA.
2. Carmen Colón Aponte was born on 26 Jan 1931 in Guayama, Guayama, Puerto Rico, USA; died on 9 Aug 2009 in Edinburg, Hidalgo, Texas, USA.
3. Santos Colón Aponte was born in 1933 in Puerto Rico, USA; died on 6 Feb 2011 in Guayama, Guayama, Puerto Rico, USA.
4. Maria Constancia Colón Aponte was born in 1934 in Puerto Rico, USA; died in Puerto Rico, USA.