José married Angela Vázquez Rivera on 2 Jan 1795 in Cayey, Cayey, Puerto Rico, USA. Angela (daughter of Manuel Vázquez Rivera and Estevan Melendez Vazquez) was born in 1767 in Cayey, Cayey, Puerto Rico, ESP; died on 3 Jun 1832 in Cayey, Cayey, Puerto Rico, ESP. [Group Sheet] [Family Chart]

1. María Silvestra Santiago Vazquez was born on 31 Dec 1799 in Cayey, Cayey, Puerto Rico, USA; died about 1879 in Cayey, Cayey, Puerto Rico, USA.
2. María Josefa Santiago Vázquez was born on 29 Apr 1798 in Cayey, Puerto Rico, ESP; died on 13 Oct 1834 in Cayey, Puerto Rico, ESP.