Santiago married Anacleta Flores Frayle on 26 Feb 1827 in Juncos, Puerto Rico, Province of Spain. Anacleta (daughter of José Flores Pena and Antonia Frayle Ramos) was born about 1806 in Juncos,Puerto Rico, Province of Spain; died on 3 May 1888 in Humacao, Puerto Rico, Province of Spain. [Group Sheet] [Family Chart]

1. Juan de Jesus Medina Flores was born in Jan 1828 in Juncos, Puerto Rico, Province of Spain; died in Jan 1828 in Puerto Rico, Province of Spain.
2. Vicente Ferrer Medina Flores was born about 1835 in Juncos,Puerto Rico, Province of Spain.